Research progress on molecular signal transduction mechanism of epilepsy ⁃ related microglia

Abstract

Existing studies have proved that microglia plays an important role in the occurrence and development of epilepsy, which shows that activated microglia can release inflammatory factors, mediate cell phagocytosis and apoptosis, and affect the activity and number of neurons, so as to promote recurrent and persistent seizures. This article reviews the signal pathways mediated by microglia related to epilepsy and sort out the role of microglia molecular mechanism in the occurrence and development of epilepsy.

DOI: 10.3969/j.issn.1672⁃6731.2023.10.013