Research progress on the interaction mechanism between ubiquitin ⁃ proteasome system and autophagy system after traumatic brain injury

Abstract

The ubiquitin ⁃ proteasome system (UPS) and autophagy system are two systems in eukaryotic protein quality control, both of which can play a biological role independently and also closely related, and play a key role in clearing abnormal proteins and secondary injury mechanism of nerve cells after traumatic brain injury (TBI). This article reviews the mechanism and interaction of UPS and autophagy system in secondary injury after TBI, in order to provide theoretical basis for protecting nerve function and improving prognosis after TBI.

DOI: 10.3969/j.issn.1672⁃6731.2023.10.004