Research of deep brain stimulation in the treatment of drug⁃resistant epilepsy

Abstract

Deep brain stimulation (DBS), an important form of neuromodulation therapy, provides a new treatment option for drug⁃resistant epilepsy (DRE) patients through precisely selections the stimulation target. By implanting electrodes at specific targets and releasing electrical stimulation, DBS can regulate the excitability of the relevant nuclei and neural circuits in the process of seizure, so as to exert the effect of controlling seizure. At present, some clinical and laboratory evidence has been accumulated on the regulatory mechanism of DBS in the treatment of DRE, the individualized selection of stimulation targets for different types of seizures, the curative effect and adverse events. This article will elaborate the above three aspects, in an effort to promote the application of DBS in DRE.

doi：10.3969/j.issn.1672⁃6731.2023.03.005