Advances in cell transplantation therapy and gene therapy in Parkinson's disease

Bao⁃lei XU, Piu CHAN

Abstract


The role of cell transplantation therapy and gene therapy in the treatment of Parkinson's disease (PD) has attracted more and more attention. It has developed from laboratory research tools to clinical products for patients. The purpose of cell transplantation therapy in PD is to replace degenerated midbrain dopamine neurons and restore dopamine neurotransmission in the denervation of the nigrostriatal pathway. Gene therapy works by introducing genetic material to slow down the degeneration of dopamine neurons and restore dopaminergic signaling transduction. Using neurotrophic factor and delivery methods for neurotrophic factor have entered clinical trials. It can also intervene in the pathological process of α⁃synuclein (α⁃Syn) mediated neurodegeneration. This paper reviews the latest progress of cell transplantation therapy and gene therapy for PD, and looks forward to the future treatment strategies.

 

doi：10.3969/j.issn.1672⁃6731.2022.04.005


Keywords


Parkinson disease; Cell transplantation; Genetic therapy; Nerve growth factor; Alpha⁃synuclein; Review

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