Significance of adipose tissue-derived stem cells regulate CD4+ T cell immune in the treatment of multiple sclerosis

Yong-lin XIE, Yong BI, Xu ZHANG

Abstract


Adipose tissue-derived stem cells (ADSCs) are genetically engineered seed cells with immunomodulatory effects, widely used in the treatment of autoimmune diseases. This article focuses on the immunomodulatory effects of adipose tissue-derived stem cells on CD4+ T cell subsets, including T helper cell (Th) 1, 2, 17 and regulatory T cell (Treg), and its clinical significance in the treatment of multiple sclerosis.

 

doi: 10.3969/j.issn.1672-6731.2014.10.005


Keywords


Mesenchymal stem cells; Adipocytes; T-lymphocytes; Multiple sclerosis; Encephalomyelitis, autoimmune, experimental; Review

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