Correlation analysis between the APN polymorphism and traditional Chinese medicine syndromes in acute ischemic stroke patients of Xinjiang Uygur and Han nationalities

Abstract

Objective To analyze the characteristics and variation of traditional Chinese medicine (TCM) syndromes in acute ischemic stroke patients of Xinjiang Uygur and Han nationalities, and to investigate the polymorphism of adiponectin (APN) of loci rs182052, rs6444175, rs1501296 and its correlation with TCM syndromes.  Methods A total of 210 patients with acute ischemic stroke (89 cases of Uygur nationality and 121 cases of Han nationality) were collected for information of TCM syndromes according to the "Diagnostic Scale for TCM Syndromes of Ischemic Stroke", and the APN single nucleotide polymorphism (SNP) of patients was detected by SNaPshot technology. The TCM syndromes between patients of Uygur and Han nationalities were compared and the correlation between TCM syndromes and APN SNP or allele frequency was analyzed.  Results 1) There were different TCM syndromes during acute ischemic stroke between patients of Uygur and Han nationalities. The TCM syndromes in Uygur patients were based on phlegm, while the syndromes in Han patients were based on Qi deficiency. Most of Uygur patients had 2 accumulated TCM syndromes in the middle and late phase of acute ischemic stroke, which was significantly different from Han patients, who mainly had 3 accumulated TCM syndromes. 2) The genotypes of APN were not correlated with TCM syndromes accumulation in Uygur patients, while the genotypes of APN rs6444175G/A and rs1501296G/A were correlated with TCM syndromes accumulation in Han patients. The allele frequency of all three APN genotypes were not correlated with TCM syndromes accumulation in both Uygur and Han patients.  Conclusions There are different distributions of TCM syndromes and its accumulation between Uygur and Han patients, and the accumulations of TCM syndromes of acute ischemic stroke in Uygur and Han patients are correlated with different APN genotypes.

doi: 10.3969/j.issn.1672-6731.2014.07.012