Angiocentric glioma: one case report and review of the literatures

Abstract

Objective To explore the clinicopathological features of angiocentric glioma. Methods The clinical manifestations, radiologic and histopathological features and immunohistochemical results were analyzed in one case of angiocentric glioma, with reviewing of the related literatures. Results The patient was a 12-year-old girl with a 2-year history of instability of right hand and 1-year history of onset of syncope associated with twitching limbs. Magnetic resonance imaging (MRI) examination showed T1-hypointense and T2-hyperintense lesions in the left temporal-parietal lobe without obvious enhancement. Morphologically, the tumor was of diffuse growth pattern, with no boundary with normal brain tissue. The tumor was formed by monomorphous bipolar spindle cells arranged in fascicles and pseudorosettes surrounding blood vessels. Tumor cells were well-differentiated, but showed an infiltrating biological behavior. No mitosis was apparent. Microvascular proliferation and necrosis were absent. Immunohistochemically, tumor cells were reactive for glial fibrillary acidic protein (GFAP), nestin and EMA, and the latter showed an characteristic 'dot-like' pattern. Tumor cells were negative for cytokeratin (CK), E-cadherin, synaptophysin (Syn), neurofilament (NF), NeuN and P53. Ki⁃67 labelling index was less than 1%. Conclusion Angiocentric glioma has both the features of ependymoma and diffuse astrocytoma. Its diagnosis mainly depends on histopathologic analysis and immunohistochemical staining.

DOI：10.3969/j.issn.1672⁃6731.2011.06.004