Clinical observation of the combined treatment of edaravone and ozagrel sodium in acute ischemic stroke beyond the thrombolytic time window

Abstract

The curative effect of edaravone combined with ozagrel sodium on acute ischemic stroke beyond the time window of thrombolysis was investigated. A total of 100 patients with acute ischemic stroke beyond the time window of thrombolysis were admitted in our hospital from December 2010 to December 2012. The patients were divided into combined treatment group (N = 50) and ozagrel sodium monotherapy group (control group, N = 50). After 14 days' treatment, total effective rate of the combined treatment group (92% , 46/50) was significantly higher than that of the control group (66% , 33/50; χ 2 = 10.780, P = 0.029). After treatment, the nerve function defect score was significantly improved in comparison with before treatment in both groups, but the improvement in combined treatment group (8.21 ± 3.58) was much better than that in the control group (14.60 ± 4.39; t = 7.976, P = 0.000). Therefore, treatment of edaravone combined with ozagrel sodium for patients with acute ischemic stroke beyond the thrombolytic time window can significantly raise the curative effect and improve the neurological function of these patients.