Imaging and clinical characteristics of sporadic Creutzfeldt-Jakob disease

Yan GAO, Wei ZHANG, Juan FENG, Shun-chang HAN

Abstract


Five patients with sporadic Creutzfeldt-Jakob disease (sCJD) presented rapidly progressive dementia which were subacute onset from 1 to 4 months. Among these cases, periodic synchronous discharge (PSD) of electroencephalography (EEG) was seen in 2 patients. Besides, 4 patients obtained positive results in cerebrospinal fluid (CSF) analysis for 14-3-3 protein. The cranial MRI examination showed symmetrical or asymmetrical colored-ribbon-shaped high signals in cerebral cortex or basal ganglia by diffusion weighted imaging (DWI), suggesting that DWI had high sensitivity and specificity for the diagnosis of sCJD as a preferred method in the clinical examination of sCJD.

Keywords


Creutzfeldt-Jakob syndrome; Diffusion magnetic resonance imaging

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