Research progress in molecular mechanisms of epileptogenesis

Chun⁃hong SHEN, Shuang WANG, Yi GUO, Mei⁃ping DING, Zhong CHEN

Abstract


Epilepsy is a common disease of nervous system, which is characterized by seizures resulting from abnormal, excessive or hypersynchronous neuronal activity in the brain. Molecular mechanism of epileptogenesis is always the focus of global neuroscientific researches. Epilepsy has various kinds of pathogenesis, with complicated molecular mechanism, involving ion channel, glutamatergic system, γ⁃aminobutyric acid (GABA) system, neurotrophic factor, inflammatory mediator and other relevant aspects. The article summarizes the molecular mechanism of epileptogenesis, further aiming to discover the new type of antiepileptic drugs (AEDs).

DOI：10.3969/j.issn.1672⁃6731.2012.05.004

Keywords


Epilepsy; Molecular biology; Review

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