Predictive value of hemorrhage in brain neoplasms assessed by microvascular permeability with perfusion CT

Abstract

Objective To explore the prediction of hemorrhage in brain neoplasms by microvascular permeability with perfusion CT imaging. Methods Retrospectively analysed the perfusion CT of 24 cases of tumors in central nervous system (CNS) confirmed by operation and pathological examination. There were 10 cases with hemorrhage and 14 cases without hemorrhage in brain neoplasms. The relationship between the permeability surface (PS) and hemorrhage in brain neoplasms was observed and analysed. Results The lesion size varied from 3 to 8 cm. The tumors showed iso⁃ or hypo⁃density, and hemorrhage lesion presented hyper⁃density on CT plain scan. On enhanced scans, hemorrhage in tumor showed phanero⁃enhancement, while tumor presented heterogeneous enhancement. The hemorrhage lesion was rich in blood supply. PS value of hemorrhage in brain neoplasms [(24.55 ± 4.74) ml/(100 g·min)] were significantly higher than that without hemorrhage [(15.06 ± 5.48) ml/(100 g·min); t = 4.412, P = 0.001]. Conclusion Microvascular permeability can quantify the defect of blood ⁃ brain barrier (BBB) at tumor lesion. The position where PS value increases obviously may predict the risk for hemorrhage in brain neoplasms.

DOI：10.3969/j.issn.1672-6731.2010.05.010