Advance on association between 5 ⁃ hydroxytryptamine and non ⁃ motor symptoms in Parkinson's disease

Abstract

Parkinson's disease (PD) is a common neurodegenerative disease in clinical practice. Patients with PD are usually accompanied by non ⁃ motor symptoms (NMS) such as gastrointestinal dysfunction, hyposmia, sleep disorders, depression, pain and hallucinations, which seriously reduce the quality of life. Recent studies have found that PD patients were accompanied by diffuse pathological changes in non⁃dopaminergic system such as progressive degeneration of 5⁃hydroxytryptamine (5⁃HT) ergic neurons, and 5⁃HT plays an important role in the regulation of emotion, cognitive function, pain and other neural functions, and is closely related to non⁃motor symptoms of PD. This article reviews the correlation between 5 ⁃HT and non ⁃motor symptoms of PD and its research progress, in order to further clarify the pathogenesis of non⁃motor symptoms of PD and provide a theoretical basis for the treatment of PD.

DOI: 10.3969/j.issn.1672⁃6731.2024.06.013