Role of melatonin in pathological injury mechanism of Alzheimer's disease

Abstract

Melatonin is an important hormone regulating sleep and wake cycle, which can alleviate and delay the progression of Alzheimer's disease (AD) by reducing amyloid ⁃ β protein (Aβ) deposition, inhibiting tau protein hyperphosphorylation, alleviating oxidative stress damage and inflammatory response, improving cholinergic system function, regulating neuronal autophagy, and other mechanisms. This article reviews the role of melatonin in the pathological injury mechanism of AD, so as to explore the clinical application prospect of melatonin in AD.

DOI: 10.3969/j.issn.1672⁃6731.2023.08.007