Advances on the correlation between epilepsy and cortical spreading depression

Abstract

Cortical spreading depression (CSD) is a pathological depolarization wave caused by the collective depolarization of neurons that propagates slowly along the cerebral cortex and can transiently inhibit brain electrical activity, which is related to a variety of paroxysmal encephalopathy. CSD and epileptiform discharge are co ⁃ occurring electrophysiological phenomena. Factors causing CSD can also induce epileptic seizure. Inhibiting the occurrence and propagation of CSD may change the seizure threshold and reduce epileptic seizure, and the two are interrelated and interact on each other. This article reviews the research progress of the correlation between epilepsy and CSD, in order to improve the clinical understanding of the correlation between them.


DOI: 10.3969/j.issn.1672⁃6731.2023.05.015