Progress on clinical characteristics and pathogenesis of cerebral cavernous malformation in children

Abstract

Cerebral cavernous malformation is the second most common vascular malformation of the central nervous system. The main clinical manifestations in children include epileptic seizure, spontaneous cerebral hemorrhage, and focal neurological deficits. The lesions are mostly single or multiple, most of which were detected incidentally. MRI has a high discrimination of cerebral cavernous malformation and is the imaging modality of choice for it. However, the pathogenesis has not been elucidated and the treatment methods still lack summary. This paper reviews the clinical characteristics and pathogenesis of cerebral cavernous malformation in children, involved clinical characteristics, imaging features, potential pathogenesis and treatment methods, to deepen the understanding of cerebral cavernous malformation for further individual treatment.

DOI: 10.3969/j.issn.1672⁃6731.2023.05.003