Alzheimer's disease related heart structural and functional damage

Shu⁃yu LIU, Wei ZHANG

Abstract


Alzheimer's disease (AD) is a common neurological degenerative disease that can cause structural and functional abnormalities of the heart. Amyloid⁃β protein (Aβ) and AD⁃related gene variants play important roles in the pathophysiological changes of the heart associated with AD. This paper reviews the structural and functional damage of the heart associated with AD and its possible mechanism of action, providing theoretical basis for a comprehensive understanding of AD and exploring new drugs and therapeutic targets.

 

doi：10.3969/j.issn.1672⁃6731.2023.04.003


Keywords


Alzheimer disease; Heart diseases; Amyloid beta⁃peptides; Presenilins; Apolipoproteins E; Review

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