Clinical research progress on subjective cognitive decline

Qing, LIU, Ping SUN

Abstract


Subjective cognitive decline (SCD) refers to the preclinical stage of Alzheimer's disease (AD) in which patients have the chief complaint of cognitive decline but no objective manifestations. It is considered to be an earlier stage of mild cognitive impairment (MCI) than the preclinical stage of AD, and the risk of progression to AD is higher. At present, there is a limited understanding of SCD in China. This paper reviews the concept of SCD, the status quo of epidemiological research, research framework, related risk factors, its relationship with AD, as well as the progress of neuropsychological tests and imaging research, so as to provide the possibility for the early clinical diagnosis and treatment of AD.

 

doi：10.3969/j.issn.1672⁃6731.2023.04.002


Keywords


Cognition disorders; Alzheimer disease; Dementia; Review

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