Progress on relationship between inflammation and severe cerebral venous thrombosis

Abstract

Severe cerebral venous thrombosis (CVT) is a rare type of stroke with poor prognosis and high mortality. The pathophysiological mechanism of severe CVT at present only focus on the onslaught of CVT as a venous return disorder and fails to elucidate the process of occurrence and development of the disease. Recently, studies on the relationship between severe CVT and inflammation have found that inflammation is involved in the pathophysiology of severe CVT, and a variety of inflammatory markers are correlated with its poor prognosis, suggesting that targeted inflammation therapy for severe CVT is a very promising treatment. This paper reviews the basic and clinical research on the relationship between inflammation and severe CVT to understand the role of inflammation in the pathophysiology of severe CVT and provide ideas for the development of new treatment strategies for severe CVT.

doi：10.3969/j.issn.1672⁃6731.2022.06.004