Dynamic brain function analysis based on resting ⁃ state fMRI and its application in neurodegenerative diseases

Abstract

Neurodegenerative diseases are a group of disorders in which progressive loss of neurons due to abnormal protein deposits causes structural and functional changes in the brain, including Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). In brain imaging studies of neurodegenerative diseases, resting ⁃ state fMRI (rs ⁃fMRI) has been widely used, with most studies analysing static features of brain function. However, the human brain is dynamic and its neural activity is non ⁃ stationary, and static studies can not reveal the time ⁃ varying features of brain function. In recent years, many studies have used dynamic analysis of brain function based on rs ⁃fMRI in order to reveal the dynamic nature of complex neural activity in the brain and further investigate the pathophysiological mechanisms and diagnostic markers of disease. In this paper, we will briefly introduce the rs ⁃fMRI analysis method, the common methods of rs ⁃fMRI ⁃ based dynamic analysis of brain function and its application and research progress in common neurodegenerative diseases.

doi：10.3969/j.issn.1672⁃6731.2022.03.003