Alarming signs and biomarkers of isolated rapid eye movement behavior disorder transforming into α⁃syncleinopathies

Abstract

α-synucleinopathies are a group of common neurodegenerative diseases. Once diagnosed, the disease's pathology is already in the middle or late stages, and the best timing for disease modification therapy is missed. Thus, it is very important to explore the early warning signs or early markers of α-synucleinopathies. Isolated rapid eye movement behavior disorder (iRBD) is the prodromal phase of α-synucleinopathies and may serve as an early warning for future transforming into α-synucleinopathies at this stage. The early warning mechanisms for the iRBD transforming into α-synucleinopathies in terms of non-motor symptoms, neuroimaging markers, neuro biological markers, and genetics are illustrated through perspective studies.

doi：10.3969/j.issn.1672⁃6731.2022.03.002