Progress in early diagnosis and management of sleep disorder in patients with Alzheimer's disease

Shi TANG, Yi⁃feng DU

Abstract


Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and mental behavioral impairment. Sleep disorder is not only a common clinical symptom of AD, but also a risk factor for accelerating the pathological progression of the disease and cognitive impairment. As there is no effective intervention target for AD at present, sleep disorder is a controllable risk factor for AD, and early and correct diagnosis and management of sleep disorder play a key role in delaying the progression of AD. This article reviews the clinical manifestations, risk factors, early screening and management of sleep disorder in AD, in order to explore new therapeutic targets for AD from the perspective of sleep.

 

doi：10.3969/j.issn.1672⁃6731.2021.12.004


Keywords


Alzheimer disease; Sleep disorders; Amyloid beta⁃peptides; Tau proteins; Review

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