Interpretation on circumscribed astrocytic gliomas in the 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition)

Abstract

In the 2021 WHO Classification of Tumors of the Central Nervous System (fifth edition), the term "circumscribed" was used to classify astrocytic gliomas with localized growth characteristics. So far, the descriptions of "diffuse" and "circumscribed", which define the growth mode, have been applied to the classification of gliomas. This paper interprets the content of circumscribed astrocytic gliomas in the new edition tumors classification, introduces the definitions and clinical characteristics of high ⁃ grade astrocytoma with piloid features and astroblastoma, MN1⁃altered, and analyzes the value and significance of molecular markers and gene changes in the diagnosis and treatment of circumscribed astrocytic gliomas.

doi：10.3969/j.issn.1672⁃6731.2021.09.010