Analysis of risk factors for asymptomatic deep venous thrombosis in patients with acute ischemic stroke

Abstract

Objective To explore the risk factors for asymptomatic deep venous thrombosis (DVT) in patients with acute ischemic stroke and determine the predictive value of risk indicators. Methods Two hundred thirty ⁃ nine acute ischemic stroke patients admitted to Beijing Shijitan Hospital, Capital Medical University from September 2018 to June 2019 met the inclusion criteria. According to the Doppler ultrasound results 7 d after admission, all eligible patients were screened for the presence of asymptomatic DVT. Univariate and multivariate Logistic regression analyses were used to identify risk factors for asymptomatic DVT. The value of risk factors for predicting asymptomatic DVT was analyzed by receiver operating characteristic curve (ROC) analysis. Results Thirty⁃seven (15.48%) patients with acute ischemic stroke had asymptomatic DVT. The multivariate forward Logistic regression analysis showed elevated D ⁃ dimer level on admission was the critical risk factor for asymptomatic DVT (OR = 1.012, 95%CI: 1.011-1.013; P = 0.000). The cut⁃off value for plasma D⁃dimer in diagnosing asymptomatic DVT in the acute ischemic stroke patients was 343 ng/ml (sensitivity = 0.784, specificity = 0.901), and the area under the ROC curve was 0.89 ± 0.03 (95%CI: 0.846-0.929, P = 0.000). Conclusions D⁃dimer is an essential marker of asymptomatic DVT in patients with acute ischemic stroke. Its elevated level is a potential risk factor for asymptomatic DVT.

doi：10.3969/j.issn.1672⁃6731.2021.07.011