Challenge of the diagnosis of aseptic meningitis and antibody negative autoimmune meningitis

Abstract

In recent years, with the improvement of the understanding and diagnosis of autoimmune⁃associated meningoencephalitis, the diagnosis and treatment of the disease has been significantly improved. However, for patients who have not found a clear pathogen and have negative autoimmune antibodies, they are often overdiagnosed as autoimmune encephalitis with negative antibodies, while diagnosis of aseptic meningitis is neglected which causes a delay of treatment. This article discusses pathogenesis, clinical symptoms, diagnostic techniques and prognosis of aseptic meningitis and antibody negative autoimmune encephalitis from different perspectives, in order to improve the clinical differential diagnosis ability.

doi：10.3969/j.issn.1672⁃6731.2021.05.001