Histopathological research progress of thrombus retrieved by mechanical thrombectomy from patients with acute ischemic stroke

Abstract

Stroke is the second leading cause of death in the world and the main cause of death in China. Ischemic stroke accounts for 70% of the total number of stroke. Endovascular mechanical thrombectomy has been recognized as an effective treatment for acute ischemic stroke (AIS) recently, however, the percentage of patients who were subject to poor prognosis and had relatively high morbidity and mortality is about 50%. The development of mechanical thrombectomy makes it possible to collect thrombus retrieved from intravascular therapy for more histopathological researches. It allows more complete extraction of human thrombus for histological analysis, while avoiding the limitations of invitro and animal experiments. This article reviews the progress of thrombus histopathology, thrombus imaging, thrombus histopathology and etiology classification, thrombus histopathology and intravascular therapy, in order to explore the pathophysiological mechanism of thrombosis and provide potential targets for the diagnosis and treatment of acute ischemic stroke.

doi：10.3969/j.issn.1672⁃6731.2021.01.010