Deep brain stimulation for non⁃motor symptoms of depression and sleep disorders in Meige's syndrome

Abstract

Objective To summarize the characteristics of non ⁃ motor symptoms of Meige's syndrome（MS）, including depression and sleep disorders, and to explore the effect of deep brain stimulation (DBS) on these non⁃motor symptoms. Methods Twelve patients with MS treated with DBS were recruited from February to May 2019 in Department of Neurosurgery in Peking University People's Hospital. The Self ⁃ Rating Depression Scale (SDS) and Pittsburgh Sleep Quality Index (PQSI) were used to assess the depression and sleep disorders before surgery and 3, 6 and 12 months after surgery. Results Before surgery, 9 (9/12) patients had different degrees of depression and sleep disorders. At 3 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 6 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 12 months after surgery, 6 (6/12) patients had different degrees of depression and 10 (10/12) had different degrees of sleep disorders. There was no significant difference in the proportion of depression (χ² = 3.102, P = 0.376) and sleep disorders (χ² = 2.598, P = 0.458) before and after DBS. Conclusions Depression and sleep disorders are common in patients with MS, and there is no significant improvement after DBS.

DOI：10.3969/j.issn.1672⁃6731.2020.12.008