Efficacy and safety of thrombolysis in treatment of minor stroke

Abstract

Objective To investigate the efficacy and safety of rt⁃PA in the treatment of minor stroke patients within 4.50 h of onset. Methods A total of 90 patients with minor stroke who were hospitalized in Department of Neurology from July 2017 to December 2018 were selected. They were divided into 43 cases treated with thromplysis (thrombolytic group) and 47 cases with routine antiplatet drugs (control group). Results National Institutes of Health Stroke Scale (NIHSS) gradually decrease during 2 h and 7 d after treatment of thrombolysis. The effective percentage of thrombolytic group was 60.47% (26/34), while control group was 34.04% (16/47), the diference was significant (χ2= 6.299, P =0.012). The proportion of good outcome were 90.70% (39/43) in thrombolytic group and 65.96% (31/47) in control group, and the difference was significant (χ2 = 7.952, P = 0.005). There were 5 cases of gingival bleeding in the thrombolytic group, no complications of intracranial hemorrhage and death, indicating that thrombolysis in minor stroke did not increase the risk of intracranial hemorrhage and mortality. Conclusions rt⁃PA intravenous thrombolysis is safe and effective for the treatment of minor stroke patients within 4.50 h of onset.

DOI:10.3969/j.issn.1672⁃6731.2020.10.010