Distribution and drug resistance of cerebrospinal fluid pathogenic bacteria in hospitalized patients

Abstract

Objective Retrospective analysis of the distribution of cerebrospinal fluid (CSF) pathogens and drug sensitivity test results in hospitalized neurosurgery patients, to provide a scientific basis for rational drug use. Methods A total of 2733 CSF specimens were collected from 2653 hospitalized patients with intracranial infection for bacterial identification and drug sensitivity tests from January 2016 to June 2018. Results A total of 207 pathogenic bacteria were isolated and the positive detection rate was 7.57% (207/2733). Among them, 115 strains of Gram ⁃ negative bacilli accounted for 57.21% (115/207), including 51 strains of Acinetobacter baumannii, 23 strains of Escherichia coli, 17 strains of Pseudomonas aeruginosa, 12 strains of Klebsiella pneumoniae, 7 strains of Enterobacter and other 5 cases; 86 strains of Gram ⁃ positive cocci accounted for 41.55% (86/207), 25 strains of Coagulase ⁃ negative staphylococci, 23 strains of S taphylococcus aureus, 19 strains of Streptococcus pneumoniae, 16 strains of Enterococcus, and other 3 cases; 1 strains of Gram ⁃ positive bacterium; 5 strains of Fungi. The resistance rates of Gram ⁃ negative bacilli to penicillins and cephalosporins were over 30% . The resistance rates of Gram ⁃ positive cocci to macrolides were over 40% . Conclusions Pathogens of intracranial infection were widely distributed and the rate of drug resistance was high. The drug resistance of hospitalized patients should be closely monitored and antibiotics should be used reasonably.DOI：10.3969/j.issn.1672⁃6731.2020.05.014