Research progress of cancer⁃associated ischemic stroke

Abstract

Nowadays, cancer and cardiovascular disease are great contributors to burden of disease with high morbidity and mortality in China. Being affected by both stroke and cancer can be devastating. The association between cancer and venous thrombosis has been previously well described. Recently, cancer has been considered to be increasingly related to arterial thromboembolism or thrombosis. Several studies have shown the characteristics of vascular risk factors, clinical manifestations, biomarkers and neuroimaging in patients with ischemic stroke and cancer. However, there is still insufficient recognition of cancer ⁃associated ischemic stroke (CAIS) in our country. Moreover, the underlying mechanisms of CAIS are uncertain, which makes the optimal strategies to diagnose, treat and prevent ischemic stroke in cancer patients still unestablished. This review summarized the current research evidence on epidemiology, clinical and imaging characteristics, mechanism, treatments and prognosis in patients with CAIS, aiming to reveal the research progress and knowledge gaps, as well as the potential strategies to solve these problems.DOI：10.3969/j.issn.1672⁃6731.2020.04.017