The effect of QST classification on serum sodium disorders following removal of craniopharyngioma in children

Abstract

Objective To investigate the characteristics of serum sodium disorders in children with different QST types of craniopharyngioma (CP). Methods There were 48 children underwent resection of CP from January 2016 to June 2017 were analyzed retrospectively. Statistical methods were used to evaluate the differences in serum sodium disorders among QST classification following removal of CP. Results There were 27 cases (56.25% ) had postoperative hyponatremia, including 12 cases (25% ) of moderate or severe, and 32 cases (66.67%) of hypernatremia, of which 16 cases (33.33%) were moderate or severe. There were significant differences in incidence of hyponatremia ( χ 2 = 11.420, P = 0.003) and hypernatremia (χ2 = 15.702, P = 0.000) in children with different QST types of CP. Among them, incidence of moderate ⁃ severe hyponatremia ( Z = ⁃ 3.324, P = 0.001) and moderate ⁃ severe hypernatremia ( Z = ⁃ 3.874, P = 0.000) of type T was significantly higher than that of type Q. Logistic regression analysis showed that QST classification was an influential factor for moderate ⁃severe serum sodium disorders after operation, and type T was a risk factor ( OR = 315.422, 95% CI: 16.804 5920.786; P = 0.000). Conclusions Long ⁃ term monitoring of serum sodium levels is necessity in children after removal of CP. Grasping the QST classification is in favour of comparing and predicting the regularity and severity of postoperatively sodium imbalance. Children with type T CP may be more likely to suffer moderate ⁃severe serum sodium disorders after surgery.DOI：10.3969/j.issn.1672⁃6731.2020.04.007