Current research status and developmental direction of animal models of cerebral venous sinus thrombosis

Abstract

The pathogenesis and pathophysiological process of cerebral venous sinus thrombosis (CVST) are different from that of ischemic stroke. The establishment of an appropriate animal model of CVST is helpful to the further research of pathogenesis, pathophysiological process and the choice of treatment strategy. However, at present, most animal models are only short ⁃ term observations, which are not suitable for long ⁃ term studies and can not well simulate the pathogenesis and pathophysiology of human CVST. This article reviews the preparation, advantages and disadvantages of various animal models of CVST, and the current research status, in order to lay a theoretical foundation and clear development direction for the study of a new method of preparing animal models of CVST with high success rate and high fitting degree.DOI：10.3969/j.issn.1672⁃6731.2020.03.017