Frailty and inflammation

Abstract

Frailty, as a kind of geriatric syndrome, increases adverse health outcomes such as falls, depression, deformity, disability and death in the elderly. The pathogenesis of frailty is not yet clear, and chronic inflammation is considered to be the main mechanism for its occurrence and development. Inflammation induces frailty by leading to sarcopenia, obesity, a variety of chronic diseases and immune dysfunction. Nutrition support, drug therapy and exercise intervention can reduce the level of inflammatory factors, reduce the inflammatory response, thus promoting muscle growth, reduce obesity, have a certain improvement effect on frailty.

DOI：10.3969/j.issn.1672⁃6731.2020.01.010