Refractory brain metastases and leptomeningeal metastases from small cell lung cancer: one case report

Yu⁃chao MA, Jian⁃ping XIAO, Hong⁃mei ZHANG, Li⁃juan WAN, Shan LIU, Ang⁃si LIU

Abstract


Objective To summarize the diagnosis and treatment of refractory brain metastases and leptomeningeal metastases from small cell lung cancer (SCLC). Methods and Results An extensive stage SCLC male patient (44⁃year⁃old) with diffuse parenchymal meningeal metastases and large volume brain metastasis was treated with muti⁃disciplinary team (MDT), namely precise helical tomotherapy with concurrent temozolomide chemotherapy, combined with intrathecal chemotherapy and systemic therapy. After intracranial recurrent, intrathecal chemotherapy and radiotherapy were used to release the symptoms. At last, this patient died of extracranial disease and the survival time after the diagnosis of brain metastases was 16 months. Conclusions For treatment of brain or leptomeningeal metastases, comprehensive and individualized treatment are needed, and MDT treatment discussion is highly recommended.

DOI:10.3969/j.issn.1672⁃6731.2019.11.011


Keywords


Small cell lung carcinoma; Neoplasm metastasis; Meningeal neoplasms; Brain neoplasms; Radiotherapy; Antineoplastic combined chemotherapy protocols

Full Text: PDF

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.