The study of relationship between total burden of cerebral small vessel disease and plasma homocysteine

Abstract

Objective To investigate preliminarily the relationship between the total burden of cerebral small vessel disease (cSVD) and plasma homocysteine (Hcy). Methods A total of 106 patients with cSVD were consecutively enrolled from January 2015 to October 2017. Plasma Hcy test were performed in all patients. The total burden of cSVD was calculated according to the severity of lacunar infarcts, white matter lesions, cerebral microbleeds and enlarged perivascular space according to MRI. Results Patients were divided into low burden group (96 cases) and high burden group (10 cases) based on total burden scores of cSVD. The level of Hcy in plasma of high burden group was seem to be higher than that in low burden group without significant difference (t = - 1.702, P = 0.090). Univariate and multivariate stepwise Logistic regression analysis showed that Hcy level of plasm (OR =1.041, 95%CI: 0.952-1.138, P=0.381) and Hyperhomocysteinemia (OR=3.132, 95%CI: 0.740-13.259; P=0.121) could not be proved to be risk factor of increasing cSVD burden. Conclusions Although plasma Hcy cannot be considered to be one of the risk factors for cSVD based on this study, plasma Hcy need to be further investigated as a potential biomarker for cSVD.

DOI：10.3969/j.issn.1672⁃6731.2019.08.006