The study of changes of serum sex hormones and 25-(OH)-D3 levels in postmenopausal patients with benign proxysmal positional vertigo

Abstract

Objective To explore the change of serum sex hormones and 25-hydroxycholecalciferol [25-(OH)-D₃ ] level in postmenopausal female patients with benign paroxysmal positional vertigo (BPPV). Methods Electrochemiluminescence (ECL) assay was employed to detect the serum levels of estradiol (E₂), progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), and 25-(OH)-D₃ in 63 female postmenopausal BPPV patients with age 50-80 years from September 1, 2015 to February 1, 2017. Spearman rank correlation analysis was used to analyze the relation between age and E₂ , E₂ and 25-(OH)-D₃. Univariate and multivariate stepwise Logistic regression analysis were used to screen the risk factors for BPPV. Results The serum levels of E₂ [15.67 (10.96, 22.15) pg/ml] and 25-(OH)-D₃ [(24.24 ± 1.05) ng/ml] in BPPV group were lower than those in control group [E₂: 31.78 (25.60, 39.50) pg/ml, 25-(OH)-D₃: (27.62 ± 0.76) ng/ml], and the differences were statistically significant (Z = -6.768, P = 0.000; t = -2.605, P = 0.010). There was no significant difference on progesterone,  LH and FSH between 2 groups. Correlation analysis showed there was no relation between E₂ and 25-(OH)-D₃ levels in both groups. There was a negative correlation between age and E₂ in control group (r_s = -0.263, P = 0.038), but no correlation in BPPV group. Multivariate Logistic regression analysis showed decreased serum E₂ and 25-(OH)-D₃ levels maybe the risk factors for postmenopausal female BPPV patients. Conclusions E₂ and 25-(OH)-D₃ deficiency are independent risk factors for BPPV in postmenopausal female patients.

DOI: 10.3969/j.issn.1672-6731.2019.01.007