Blood-brain barrier destruction and formation of perihematomal edema after intracerebral hemorrhage

Abstract

The perihematomal edema (PHE) after intracerebral hemorrhage (ICH) is one of the manifestations of secondary brain injury. It is generally believed that the formation of PHE is due to the destruction of blood-brain barrier (BBB) after ICH, which in turn leads to the formation of vasogenic edema. At present, the methods for quantitatively evaluating the permeability of BBB include imaging evaluation and biological marker evaluation, both of which can be used as an important way to study the relationship between BBB and PHE. The ultimate goal of studying the relationship between BBB destruction and PHE is to find treatments that can prevent BBB destruction and reduce PHE after ICH.

DOI: 10.3969/j.issn.1672-6731.2018.11.004