The role of DISC1 gene in growth of neural stem cells and epileptogenesis

Abstract

Disrupted in schizophrenia 1 (DISC1) is widely expressed in brain, and plays a role in multiple process of neurogenesis such as proliferation, migration, differentiation and maturation. DISC1 gene was found not only associated with mental disorders, such as schizophrenia, bipolar disorder and major depressive disorder, but also correlated with some neurological diseases, such as epilepsy. Our team have made efforts to clarify how DISC1 gene works in the regulation of neurogenesis and epileptogenesis. Here, we reviewed the DISC1 function on the development of neural stem cells (NSCs) and epileptogenesis.

DOI: 10.3969/j.issn.1672-6731.2018.01.005