Clinical study on treating post-stroke sleep disorders by fastigial nucleus stimulation

Abstract

Objective To discuss the efficacy and safety of fastigial nucleus stimulation (FNS) in the treatment of post-stroke sleep disorders (PSSD). Methods A total of 69 cases with PSSD were randomly divided into 3 groups: control group (N = 23), sham group (N = 23) and treatment group (N = 23). Control group received routine treatment, sham group received routine treatment plus sham FNS treatment, and treatment group received routine treatment plus FNS treatment. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of patients in 3 groups before and after 4-week treatment. Adverse reactions during the FNS treatment were also observed. Results There was statistical significance in PSQI scores among 3 groups before and after 4-week treatment (P = 0.020). PSQI score after 4-week treatment in treatment group was significantly lower than control group and sham group (P = 0.000, 0.000). Compared to before treatment, PSQI scores were significantly decreased in 3 groups after 4-week treatment (P = 0.000). Conclusions FNS safely and effectively improves the sleep quality of patients with PSSD, thus it can be used as one of the auxiliary treatments for curing PSSD.

DOI: 10.3969/j.issn.1672-6731.2017.03.006