Parkinson's disease and risk of brain tumor: a Meta-analysis

Abstract

Objective To assess the correlation between Parkinson's disease (PD) and brain tumor. Methods Taking Parkinson's disease, tumor, cancer in Chinese, and PD, Parkinson's disease, tumor, cancer, neoplasm in English as the key words, prospective cohort studies and case -control studies on relation between PD and brain tumor were searched by using PubMed, Web of Science, EMBASE/SCOPUS, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP database from January 1965 to July 2016, assisted by manual searching. Quality assessment and Mete-analysis were made by using Newcastle-Ottawa Scale (NOS) and Stata 12.1 software. Results A total of 11 studies with a total number of 350 632 PD patients were included in the overall analysis after excluding duplicate ones and those which did not meet the inclusion criteria from 1832 articles. Meta-analysis showed that compared with healthy people, PD patients had an increased risk of brain tumor (OR = 1.370, 95%CI: 1.120-1.690; P = 0.003), and the result was consistent after excluding 2 low-quality articles (OR = 1.360, 95% CI: 1.080-1.720; P = 0.008). Further stratified analyses according to disease onset time and regional difference showed that brain tumor occurrence in PD patients was significantly higher than healthy people only after the diagnosis of PD (OR = 1.430, 95% CI: 1.120-1.830; P = 0.004). The geographical subgroup analyses showed a higher risk of brain tumor among PD patients in Europe (OR = 1.420, 95%CI: 1.290-1.560; P = 0.000) and Taiwan area of China in Asia (OR = 2.590, 95% CI: 1.730-3.880; P = 0.000) compared with healthy people. Funnel plot, Begg test (P = 0.583) and Egger test (P = 0.985) showed there was no bias. Conclusions PD patients have a higher risk of brain tumor.

DOI: 10.3969/j.issn.1672-6731.2017.01.006