Effect of butylphthalide on the serum uric acid and clinical outcomes of patients with ischemic stroke

Abstract

Objective To investigate the effect of butylphthalide on the serum uric acid level and clinical outcomes of patients with ischemic stroke.  Methods A total of 160 patients with ischemic stroke were randomly divided into 2 groups: treatment group and control group. Patients in treatment group were given butylphthalide injection with the dosage of 25 mg twice a day, and those in control group were given conventional treatment. Uricase method was used to detect the serum uric acid level, and National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological functional defect.  Results After 14-day treatment, serum uric acid level in treatment group was significantly decreased (P = 0.003), and NIHSS score was significantly reduced (P = 0.000); comparing with control group, the level of serum uric acid was significantly higher (P = 0.029), while NIHSS score was significantly lower (P = 0.000). Pearson correlation analysis showed the level of serum uric acid was negatively correlated with NIHSS score (r = -0.288, P = 0.009). Conclusions Butylphthalide injection can promote the recovery of neurological function in patients with ischemic stroke, which may be related to decreasing the resistance to antioxidants.

DOI: 10.3969/j.issn.1672-6731.2016.09.014