Clinical analysis of 48 cases with Guillain-Barré syndrome

Abstract

Forty-eight patients diagnosed as Guillain-Barré syndrome (GBS) in our hospital were retrospectively analyzed, including clinical manifestations, laboratory tests, neuroelectrophysiological tests, treatment and prognosis. In these patients, 81.25% (39/48) started with limb weakness or numbness, especially prominent for both lower limbs; 93.75% (45/48) had decreased or disappeared tendon reflex. Cerebrospinal fluid (CSF) tests showed albumin-cytological dissection in 38 patients. Neuroelectrophysiological tests in 42 patients revealed that the conduction velocity of F wave was decreased or was not elicited, the conduction velocity of motor and sensory nerves slowed down, and compound muscle action potential (CMAP) amplitude decreased. A total of 43 patients received intravenous immunoglobulin (IVIg), and 97.67% (42/43) showed improved muscle strength after treatment. A few patients showed atypical signs and symptoms for GBS, such as unilateral facial hypalgesia and positive pathological signs. Clinical manifestations, laboratory tests and neuroelectrophysiological tests should be combined to make early diagnosis and improve the prognosis.

DOI: 10.3969/j.issn.1672-6731.2016.09.011