Laboratory tests and clinical significance of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody

Jing-jing LUO, Feng GAO, Jie-xi WEN, Hong-jun HAO, Jing GUO, Yi-ning HUANG

Abstract


Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM). This article summarizes the discovery, laboratory tests and clinical significance of anti-HMGCR antibody.

 

DOI: 10.3969/j.issn.1672-6731.2016.09.005


Keywords


Hydroxymethylglutaryl CoA reductases; Immunoassay; Antilipemic agents; Review

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