Research progress of the impact of Pin1 on the pathogenesis of Alzheimer's disease

Abstract

Peptidyl-prolyl cis/trans isomerase (Pin1) has been identified as an important factor that can affect many neurodegenerative diseases as well as neoplasms. In particular, Pin1 has got a wide attention for its critical function in the occurence and development of Alzheimer's disease (AD). It has been found that Pin1 can affect the incidence of AD by adjusting the phosphorylation of tau and amyloid β-protein precursor (APP), and interfering with the cell cycle. Although a lot of clinical data suggest that Pin1 is a neuroprotective factor, some scholars point out that Pin1 may promote neuronal apoptosis, because of PIN1 gene polymorphism. In summary, Pin1 may become a new target for the treatment of AD, and has the potential to be a biomarker for the early diagnosis of AD.

DOI: 10.3969/j.issn.1672-6731.2015.08.002