Relationship between serum high-sensitivity C-reactive protein and modified TOAST classification as well as OCSP subtypes in patients with acute ischemic stroke

Abstract

This paper aims to investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) level and modified TOAST classification as well as OCSP subtypes in patients with acute ischemic stroke. Serum hs-CRP was measured in 240 patients with acute ischemic stroke and 120 normal controls. All patients were classified according to modified TOAST classification and OCSP criteria. Serum hs-CRP levels in acute ischemic stroke group were significantly higher than those in normal control group [(13.68 ± 6.92) mg/L vs (3.98 ± 0.76) mg/L; t = 6.922, P = 0.002]. Among modified TOAST subtypes, the highest serum hs-CRP level was in cardioembolism (CE) group [(16.82 ± 6.16) mg/L], followed by arterothrombosis (AT) group [(15.17 ± 5.68) mg/L], stroke of undetermined etiology (SUD) group [(10.06 ± 3.89) mg/L] and small artery disease (SAD) group [(9.86 ± 3.75) mg/L, P = 0.027]. Among OCSP subtypes, the highest serum hs-CRP level was in total anterior circulation infarct (TACI) group [(17.02 ± 6.98) mg/L], followed by posterior circulation infarct (POCI) group [(15.91 ± 7.12) mg/L], partial anterior circulation infarct (PACI) group [(12.83 ± 4.95) mg/L] and lacunar infarct (LACI) group [(10.61 ± 5.73) mg/L, P = 0.005]. Serum hs-CRP levels are various in different modified TOAST and OCSP subtypes, which may reflect etiological and pathophysiological diversity of acute ischemic stroke, guide clinical treatment and help to predict prognosis.

doi: 10.3969/j.issn.1672-6731.2014.10.013